Our specific focus is on modulating gene function to promote cholesterol efflux from peripheral tissues (reverse cholesterol transport) via HDL, thereby alleviating the potentially deleterious ...

This modification impairs the ability of HDL to promote cholesterol efflux by the ATP-binding cassette transporter A-1 pathway. Animal studies and small-scale human studies suggest that measures ...

as well as HDL’s ability to remove cholesterol from cells (a process called cholesterol efflux capacity, or CEC). The team ...

These peptides interact with ATP-binding cassette transporters (ABCA1 and ABCG1), facilitating cholesterol efflux from peripheral tissues to high-density lipoproteins (HDL). Additionally, they can ...