Instead of just fusing two molecules, as for example in chemical ligations, the method replaces one sequence (e.g. PGAFDADPLVVEI-Strep in Figure 4) with the fusion partner. This has several advantages ...
This paper presents the important discovery that lipid metabolic imbalance caused by Snail, an EMT-related transcription factor, contributes to the acquisition of chemoresistance in cancer cells.