喜树碱是一种主要由假柴龙树属（茶茱萸科）、喜树（蓝果树科）、蛇根草属（茜草科）等植物类群产生的用于化学防御的单萜喹啉类生物碱，其通过抑制DNA拓扑异构酶I和诱导癌细胞dsDNA断裂，在治疗肺癌、肠癌等癌症方面表现出良好的抗癌活性，是继紫杉醇和长春花生 ...

Explore the challenges of ADC characterization, key techniques, and the benefits of partnering with a CDMO for effective ...

2024年9月13日-17日，欧洲肿瘤内科学会（ESMO）年会将于在西班牙巴塞罗那召开，作为肿瘤内科最高规模的国际盛会，涉及肺癌、乳腺癌、消化道肿瘤、泌尿生殖系统肿瘤等领域的多项研究届时皆将披露最新进展。

In an interview with Targeted Oncology, Mark R. Litzow, MD, discussed the incorporation of Immunotherapy into upfront acute ...

K Heran Darwin is at New York University Grossman School of Medicine and a regular columnist for EMBO reports.

Aldoxorubicin is under clinical development by LadRx and currently in Phase II for Triple-Negative Breast Cancer (TNBC).

The antibody-drug conjugate (ADC) puxitatug samrotecan (AZD8205) demonstrated a manageable safety profile consistent with ...

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...

Pivekimab sunirine is a monoclonal antibody conjugated commercialized by AbbVie, with a leading Phase II program in Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia).

Venice: Maura Delpero's sophomore feature is elegantly composed but overly sedate.