Furthermore, the presence of PARP1 condensates significantly promotes DNA ligation upon PARylation. These findings provide insight into how PARP1 condensation and PARylation regulate the assembly and ...

The target DNA is amplified by using target-specific primers. This is followed by ligation of an amplified fragment to a linearized vector containing the desired bacteriophage RNA promoter.

The CyBio FeliX, a benchtop instrument for automated liquid handling tasks, was used to automate the HaloPlex Target ...

The research results, titled "DNA Nanostructure Disintegration-Assisted SPAAC Ligation for Electrochemical Biosensing," were published in Nano Letters. In the presence of target miRNA, duplex ...

Ethanol-precipitate the DNA before ligation to concentrate the sample and remove salts that can interfere with ligation. The amount of vector obtained is usually sufficient to perform two 260-ng ...

Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States This important study employed multiple orthogonal techniques and ...

Nov. 7, 2024 — Researchers have used ancient DNA to challenge long-held interpretations of the people of Pompeii. Contrary to physical appearances, the DNA evidence revealed unexpected ...

Gene therapy can effectively treat various diseases, but for some debilitating conditions like muscular dystrophies there is ...

StitchR, a new gene therapy technique, delivers large genes in two parts to treat muscular dystrophies by restoring critical proteins in animal models.

You can edit what information becomes public or private on the site, and how you want to appear to other users if your DNA matches with someone else. You'll have an opportunity to review all ...

Discover the impact of hypereosinophilia on heart health, focusing on eosinophilic heart disease (EHD) and its mechanisms.