The molecules developed by companies in Pre-Registration, Phase II, Phase I, Preclinical, and Discovery stages are 3, 2, 1, 3, and 4 respectively. Endothelin receptor type B (EDNRB) is a G ...

Ednrb is highly expressed in satellite glial cells ... Red or green indicates adjusted p < 0.01, while gray indicates p ≥ 0.01. Endothelin B receptor inhibition increases axonal growth in vitro and ex ...

In addition to having trisomy 21, this patient was homozygous for a novel mutation in the endothelin B receptor (EDNRB) gene. A term female infant with karyotype 47,XX,+21 presented on day 3 of life ...

Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a ...

Together, the findings suggested that 17α-estradiol extensively reshaped the cell populations, cellular communication, neuropeptide secretion, and neural synapse activity in aged hypothalamus, which ...

Armingol, E., Officer, A., Harismendy, O. & Lewis, N.E. Deciphering cell-cell interactions and communication from gene expression. Nat Rev Genet 22, 71–88 (2021 ...

To the Editor: The distribution framework for glucagon-like peptide-1 (GLP-1) receptor agonists proposed by Emanuel et al. in their Perspective article (May 30 issue) 1 considers potential years ...

This increase in flow is mediated through local metabolic mechanisms and partially through adrenergic receptor mediated vasomotion. This review will focus specifically on the role played by the ...

Viking Therapeutics' VK2735, a dual GLP-1/GIP receptor agonist, shows promising results in Phase II trials for obesity treatment with potential for both subcutaneous and oral formulations.

2003). We applied CellPhoneDB (Efremova et al., 2020) to infer cell-cell communication between different cell types. The specific ligand-receptor interactions between cell types were identified based ...