The multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. [9] ...

The molecules developed by companies in Pre-Registration, Phase II, Phase I, Preclinical, and Discovery stages are 3, 2, 1, 3, and 4 respectively. Endothelin receptor type B (EDNRB) is a G ...

Figure 1. Signal transduction mechanism of EGFR (epidermal growth factor receptor) transactivation by angiotensin II (AngII) in vascular smooth muscle cells leading to vascular remodeling. Please note ...

Copyright: © 2024 The Author(s). Published by Elsevier Ltd.

Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a ...

Together, the findings suggested that 17α-estradiol extensively reshaped the cell populations, cellular communication, neuropeptide secretion, and neural synapse activity in aged hypothalamus, which ...

Copyright: © 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. Glucagon-like peptide-1 ...

2003). We applied CellPhoneDB (Efremova et al., 2020) to infer cell-cell communication between different cell types. The specific ligand-receptor interactions between cell types were identified based ...

Viking Therapeutics' VK2735, a dual GLP-1/GIP receptor agonist, shows promising results in Phase II trials for obesity treatment with potential for both subcutaneous and oral formulations.

Background: Hypoganglionosis resembles Hirschsprung disease (HSCR) which is characterized by severe constipation. Enterocolitis due to hypoganglionosis or Hirschsprung-associated enterocolitis (HAEC) ...