The system consists of cationic liposomes (carrier), doxorubicin (anticancer drug), siRNA targeted to mRNA-encoding proteins responsible for the cellular drug efflux ... to MDR1 and BCL2 mRNA.

which belongs to a family of ATP-binding cassette transporters and is the product of the mdr1 gene. These MDR proteins lead to the production of drug efflux pumps, which actively transport taxanes ...