The G1/S transition is a stage in the cell cycle at the boundary between the G1 phase, in which the cell grows, and the S phase, during which DNA is replicated. [1] It is governed by cell cycle ...

First growth phase in the eukaryotic cell cycle From Wikipedia, the free encyclopedia ...

CDK2 inhibitors have received some attention at the 2024 ESMO Congress, with one candidate, PF-07104091, showing combination potential with CDK4-selective blockade in HR–positive, HER2–negative breast ...

WEE1 acts as a master regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. By inhibiting WEE1 ...

Oct. 3, 2024 — Human stem cell transplants successfully repaired macular holes in a monkey model, researchers report. After transplantation, the macular holes were closed by continuous filling ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy ... They found a puzzling connection between ...

The study addresses the complex regulation of HSCs, highlighting p21's multifunctional nature beyond cell cycle control. Through the use of p21-tdTomato mice, researchers differentiate between p21 ...

The phase 2b study of ANKTIVA (nogapendekin alfa inbakicept-pmln) in combination with checkpoint inhibitors ... About the QUILT-3.055 Study Non-small cell lung cancer occurs when malignant cells ...

Tri-PyMT cells (p7) composed by both RFP+ and GFP+ cells were cultured in growth medium. Cell cycle analysis was performed by using EdU incorporation and Click-chemistry. Cells in G0/G1, S and G2/M ...