Purpose. The effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors were examined. Pharmacogenetics examines the relationship between single-gene polymorphisms and the ...
Email: jonsimmons{at}doctors.org.uk AIM To determine if polymorphisms in the VDR gene are associated with susceptibility to IBD SUBJECTS European Caucasoids: 158 patients with ulcerative colitis, 245 ...
The CBS gene has a variant, 844ins68, that has been linked with increased activity ... Methods: Subjects were genotyped for MTHFR using polymerase chain reaction-single strand conformation ...
Polymorphisms in the CARD15 gene have been linked to higher susceptibility for Crohn’s disease. In particular, associations have been found with ileal and fibrostenosing disease, young age at onset of ...
The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro. The ability of mutant p53 to bind ...
This data suggests that the effect of the different combinations of these polymorphisms is independent of HLA class I and class II matching. Furthermore, the effect exerted by the 2MM/GG+ combination ...