Design of clinical trials for germline gene editing stretches current accepted standards for human subjects research. Among the challenges involved is a set of issues concerning intergenerational ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. T cell receptors (TCR) and gene expression ...

Oct. 28, 2024 — Using state-of-the-art technology, researchers have identified several specific steps needed for CRISPR to become active and perform its gene editing function. These preclinical ...

The Elantra N TCR Edition maintains the standard 2.0-liter turbocharged engine, delivering 276 horsepower and 289 lb-ft of torque. Transmission options include a six-speed manual or an eight-speed ...

Understanding the importance of these lifelong financial benefits is crucial for clinicians advising veterans on germline testing. Both VA and non-VA healthcare providers should incorporate this ...

The availability of targeted therapies for advanced prostate cancer led to the expansion of national guidelines recommending germline genetic testing. The aim of this study was to describe recent ...

Slager, PhD, discusses the background of her research on inherited germline genetics for risk of chronic lymphocytic leukemia ... but not everybody progresses to CLL. So, can this genetic risk score ...

Genetic testing for germline mutations may be useful in families with a history of pancreatic cancer and guide early detection or other related cancers. These could include intensified ...

Those can direct us to PARP inhibitors when the patient is castration resistant. I think the biggest take-home message for the germline and somatic testing is we need to do more of it. Prostate is ...