Characterizing linkers for crRNA-MS2 and BoxB-petracrRNA. The upper four base pairs of the Cas9-binding region of repeat:anti-repeat duplex were altered to generate 12 pairs of ...

This important manuscript describes a creative approach using dual-component gRNAs to create a new class of molecular proximity sensors for genome editing. The authors demonstrate that this tool can ...

The team then looked at predicted structures of the sequences they tested and saw that many of them had slight variations or imperfections compared to the canonical twister ribozyme structure, yet ...

Approximately 94% of the tested ribozymes were active, and the study revealed that their function can persist even when their structure contains slight imperfections. The research team also identified ...

The team then looked at predicted structures of the sequences they tested and saw that many of them had slight variations or imperfections compared to the canonical twister ribozyme structure ...

Approximately 94% of the tested ribozymes were active, and the study revealed that their function can persist even when their structure contains slight imperfections. The research team also identified ...

The team then looked at predicted structures of the sequences they tested and saw that many of them had slight variations or imperfections compared to the canonical twister ribozyme structure ...

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