As drugmakers take lessons from oncology in developing CAR T cells for other diseases, they must contend with risks that ...

An immune response that likely evolved to help fight infections appears to be the mechanism that drives human ...

while tropic switching from R5- to X4-specific HIV-1 typically occurs in the later stages of infection as mutations in the virus allow it to shift its coreceptor usage. This switch is associated with ...

By doing so, cART reduces the amount of virus in the body to undetectable levels, thereby protecting and preserving these cells and the host's immune system,” said Dr. Jamie Mann, senior lecturer in ...

As the science stands, the vast majority of the roughly eight million people in South Africa living with HIV will have to get ...

These help you fight infections and HIV-related cancers. Your doctor can tell because your CD4 levels (sometimes called T cell levels) start to go up. Second, you become far less likely to pass ...

Therefore, the need for collaborative and interdisciplinary research focused on deciphering the multifaceted cellular, and molecular immunopathogenesis of HIV remains essential in the development of ...

The latent HIV reservoir is a major barrier to HIV cure. Combining latency reversal agents (LRAs) with differing mechanisms of action such as AZD5582, a non-canonical NF-kB activator, and I-BET151, a ...

Stem cell therapies provide hope for patients with heart disease, blindness, Parkinson's, HIV, diabetes and spinal cord ...

Unlike progressors, people who experience the expected progression of HIV to AIDS, VNPs exhibit relatively stable CD4 + T cell counts over extended periods without antiretroviral therapy, even when ...

Highly effective treatments for HIV have existed since the mid-1990s. But while these treatments keep people healthy, we do not yet have a safe and scalable way to completely rid the body of the virus ...

that translates to roughly 30%–60% CD4 T cells in relationship to 10%–30% CD8 T cells. When a person is first infected with HIV, there is generally a 30% drop in the number of CD4 T cells as HIV ...