Expansion of antigen-specific T cells (cytomegalovirus) counts for reduced repertoire diversity. B-cell functions are altered with age: antibody production, affinity and isotype switching.
The interactions between OX40 ligand (OX40L) and OX40, 4-1BBL and 4-1BB, CD70 and CD27, and TL1A and death receptor 3 (DR3), positively regulate T-cell responses ... that are specific for TNF ...
While V genes, being more diverse, contribute to a broad scope of antigen recognition, the J genes, being less diverse, could be more specific to certain antigenic epitopes. TCRclub proves to be a ...
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut. 2Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.