Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining ...

S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + Nalpha,Nalpha,Nalpha-trimethyl-L ...

程红研究组、中国科学院大连化学物理研究所李国辉研究组以及中国科学院上海营养与健康研究所王泽峰研究组的合作研究成果：“ Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers” ...

DNA methylation is the covalent addition of methyl groups to DNA bases, typically the cytosine of CpG dinucleotides. It is catalyzed by methyltransferase enzymes using a S-adenosyl methionine ...

However, it has shown limitations in terms of high costs and inefficiencies. The productivity and accuracy of DNA methylation detection rely critically on the optimization of methodologies and the ...

Alterations in lipid metabolism and DNA methylation are 2 hallmarks of aging. Connecting metabolomic, epigenomic, and aging outcomes help unravel the complex mechanisms underlying aging. We aimed to ...