No writing assistance was utilized in the production of this manuscript. Monoclonal antibodies are novel therapeutic agents used with great success in the treatment of rheumatoid arthritis (RA).

Glutamine starvation inhibits cholesterol synthesis in human cells. Glutamine, but not its derivatives nor glucose, maintains expression of the rate-limiting lipid biosynthesis enzyme HMGCR. Glutamine ...

The company aims to supercharge antibody treatments using specially designed protein “cages” that multiply their effects, opening up new opportunities in drug development. The company was spun ...

1ADC Therapeutic Development, Zymeworks Inc., Vancouver, Canada.

Therapeutic antibodies are an important alternative option, but resistance has developed owing to the emergence of viral variants. A new paper in Cell reports the development of an antibody with ...

The mixed results are a blow for bepranemab and for related antibodies that target a mid-region epitope on tau. But exploratory analyses of the results hint at a path forward for these candidates.

Ueda is holding an expandable toy that he uses to demonstrate how the company’s computationally designed Antibody Cages work. (GeekWire Photo / Alan Boyle) Three weeks after University of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In the early phase of Alzheimer’s disease, ...

A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

Pregnancy test sticks use monoclonal antibodies to tell if a woman is pregnant ...