Lipid nanoparticles made from lipids optimized via directed chemical evolution show high performance as mRNA delivery vehicles.

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids—key ...

Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans fat-induced atherosclerosis - (https:/ ...

Engineers have cooked up a new way to improve mRNA delivery, developing an optimal 'recipe' for ionizable lipids -- key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ...

Eli Lilly's oral drug muvalaplin showed significant reductions in lipoprotein(a) levels in a Phase 2 trial of 233 high-risk ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids -; key ingredients in lipid nanoparticles (LNPs), the molecules behind the ...

Scientists from the University of Geneva (UNIGE), in collaboration with the Institut de biologie structurale de Grenoble (IBS) and the University of Fribourg (UNIFR), have used cryo-electron ...

Dyslipidemia, a risk factor for cardiovascular disease, is an increased level of serum total cholesterol, low-density lipoprotein cholesterol and triglycerides, or a decreased serum high-density ...

Messenger ribonucleic acid (mRNA)-based therapeutics and the potential of mRNA as a treatment for various conditions has been ...

Conclusions and relevance Two different dietary fats (butter and coconut oil) which are predominantly saturated fats, appear to have different effects on blood lipids compared with olive oil, a ...