Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...

Diabetes drug development gets an advance in study that shows Inceptor binds excess insulin within the beta cell and directs it towards degradation.

The autophagic process has been identified as a degradative pathway: cargo, including entire organelles, is sequestered into double-membrane vesicles, known as autophagosomes, and addressed to ...

TMEM106b’s rap sheet is growing. Some of its genetic variants are linked to both Alzheimer’s disease and frontotemporal dementia, and fibrils of this lysosomal protein accumulate in several ...

Primary seminal vesicle tumors are very rare; less than 100 cases have been reported in the English literature to date. Patients usually present with lower urinary tract symptoms or hematospermia.

In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

Nov. 22, 2024 — While it's well known that sleep enhances cognitive performance, the underlying neural mechanisms, particularly those related to nonrapid eye movement (NREM) sleep, remain ...

B) Lysotracker staining marking acidic vesicles. Large, stained vesicles can be observed in the annotated area. C) The merged channels show colocalization of the RFP+ cell debris with the lysosomal ...

Nov. 19, 2024 — A research article shows that Eradivir's patent-pending antiviral therapeutic called EV25 reduces lung viral loads of advanced-stage influenza in ... Promising Daily Tablet ...