Depletion of eIF3d or eIF3e, but not eIF3h reduced the levels of multiple components of the MAPK signaling pathways. Surprisingly, however, depletion of all three eIF3 subunits increased MAPK/ERK ...

Schematic models of the core of MAPK/ERK pathway and human eIF3 complex. (A) The MAPK/ERK pathway activation by growth factors and receptor tyrosine kinases (RTKs). RTKs signal through GRB2-Sos and ...

Polyphenols can inhibit the formation of fat through signal pathway regulation and transcription factor regulation thus exerting an anti-obesity effect. Figure 3. Intrinsic regulatory mechanisms ...

This review emphasizes the crucial influence of the NF-κB signaling pathway within the TME, underscoring its roles in the development and advancement of cancer. By examining the interactions between ...

These pathways include nuclear factor- B, p38 mitogen-activated protein kinase, NH 2-terminal Jun kinases/stress-activated protein kinases, hexosamines, and others. In addition, there is evidence ...

LV specification and maintenance were also impaired in EPHB4 2YP mice. Defects in LV development were reversed by inhibition of the Ras-MAPK (mitogen-activated protein kinase) signaling pathway. In ...

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Upon binding, these receptors initiate pro-inflammatory signaling pathways such as the NF-κB and mitogen-activated protein ...

Their findings, which were published in Science Advances, also offer new insights into 2'3'-cGAMP's role in cell migration and how the newly identified 2'3'-cGAMP/Rab18/FosB signaling pathway ...

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality ...