Depletion of eIF3d or eIF3e, but not eIF3h reduced the levels of multiple components of the MAPK signaling pathways. Surprisingly, however, depletion of all three eIF3 subunits increased MAPK/ERK ...

Schematic models of the core of MAPK/ERK pathway and human eIF3 complex. (A) The MAPK/ERK pathway activation by growth factors and receptor tyrosine kinases (RTKs). RTKs signal through GRB2-Sos and ...

Newly discovered estrogen receptor-dependent signaling pathways demonstrate that estrogen functions in the cytosol as well as in the nucleus. The classic estrogen receptor signaling pathway occurs ...

When this occurs, the affected children must be operated on at an early age. In the search for the cause of CPAM, the research team pursued the following hypothesis: Variants in cancer-associated ...

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Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with cancer, ...

The following is a summary of “Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients,” published in the November 2024 issue of Hematology by ...

Exact Sciences Corp. (Nasdaq: EXAS), a leading provider of cancer screening and diagnostic tests, will present 10 abstracts demonstrating the breadth of its Precision Oncology portfolio at the 2024 ...

BACKPACKOriginal ArticleTitle:Dual-function natural products: Farnesoid X receptor agonist/inflammation inhibitor for ...