From the Department of Surgery, Tufts College Medical School, the Joseph H. Pratt Diagnostic Clinic and the New England Center Hospital. † Professor of surgery, Tufts College Medical School ...

这些结果表明，NPM1促进人类肿瘤进展。 为了阐明NPM1对肿瘤进展和抗肿瘤免疫反应的影响，研究人员利用CRISPR-Cas9系统敲除了三种小鼠肿瘤细胞系（结肠癌MC38、黑色素瘤B16F10和肺癌LLC）中的Npm1基因。通过免疫印迹确认了敲除效率。然后将野生型或Npm1缺陷的肿瘤 ...

THERE is much to be learned regarding the natural history of portal hypertension in cirrhosis. This is a natural consequence of the lack of a technic for direct measurement of portal pressure and ...

The author demonstrates that deficiency or pharmacological inhibition of O-glcNac transferase (OGT) enhances tumor immunity in colorectal cancer models. This useful study unveils that OGT deficiency ...

The findings of this valuable manuscript advance our understanding of the significance of Bestrophin isoform 4 (BEST4) in suppressing colorectal cancer (CRC) progression. The authors used appropriate ...