Additionally, miR-34a targets the PD-L1 gene. Overexpression of miR-34a following transfection for 48 hours suppressed PD-L1 mRNA expression, while Atractylodes macrocephala polysaccharide increased ...

对于低免疫原性的结直肠癌小鼠模型（MC38），PTPN22野生型小鼠接受PD-L1抑制剂治疗后仅在早期有抑制效果，随后耐药。而PTPN22 cKO小鼠接受PD-L1抑制剂 ...

目前国内免疫药物主要有PD-1单抗和PD-L1单抗两大类。大家可能觉得，这两种药物其实是针对同一免疫通路的两个端点，机制上 ...

aLaboratory for Systems Pharmacology, Harvard Medical School, Boston, MA, United States bDepartment of Medical Oncology and Center for Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA ...

League One: Mitch Pinnock scores 97th minute equaliser for Northampton at Birmingham Joe Low's header at Wigan keeps Wycombe top of the table Wrexham stay third after narrow 1-0 victory over ...

Our hybrid nanovesicles (PD-1/SIRPα NVs) demonstrated high specificity to PD-L1 and CD47 ligands, facilitating the phagocytosis of melanoma cells by macrophages. In a melanoma mouse model, PD-1/SIRPα ...

This study will focus on the treatment of newly diagnosed locally advanced primary head and neck cancer patients with no lymph node involvement and low (TPS <10) PD-L1 tumor expression.