从机制上来说，MEKi对CAR-T细胞的作用与转录重编程相关，其特征是记忆相关基因的上调，以及激活、耗竭、合成代谢相关和促凋亡基因的下调。此外，AP-1转录因子c-Fos和JunB的下调在驱动MEKi启动的转录重编程中发挥核心作用。在CAR-T细胞中 ...

SpringWorks Therapeutics (SWTX) announced that three abstracts from the pivotal Phase 2b ReNeu trial of mirdametinib, an investigational MEK ...

SpringWorks Therapeutics (SWTX) announced that data from the pivotal, Phase 2b ReNeu trial of mirdametinib, an investigational MEK inhibitor, ...

Data from the pivotal Phase 2b ReNeu trial demonstrate that patients with NF1-PN achieved deep responses and improvements in ...

引言I型神经纤维瘤病(NF1)是由NF1基因突变引起的常染色体显性遗传性疾病，患病率约为1/4000-1/2000，患者多幼年起病，临床表现以咖啡牛奶斑和多发性神经纤维瘤为特征[1]。其中约50%的患者会出现丛状纤维神经瘤（PN）[2]，NF1-PN ...

Atriva Therapeutics is starting a phase 2 trial of its MEK inhibitor ATR-002 in patients with coronavirus infections, saying the drug could help prevent patients progressing to critical-stage ...

引言胰腺癌被誉为“癌症之王”，是最致命的恶性肿瘤之一。患者对现有治疗手段表现出高度耐药性。近年来，靶向疗法在临床前实验中取得显著进展，但由于患者对靶向治疗迅速产生耐药性，这一疗法未能达到理想效果。目前已知超过90%的胰腺癌病例携带突变的KRAS基因。

Combining the checkpoint inhibitor atezolizumab with targeted therapy led to improvements in overall survival in patients with anaplastic thyroid cancer.

MEK Inhibitor-Based Treatments and FDA Approval of Selumetinib (Koselugo) Several clinical trials have investigated the effectiveness of drugs called MEK inhibitors as potential treatments for ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

Combined MEK and PI3K inhibition has had limited success in the clinic, although alternative methods of targeting these pathways may be effective. MEK inhibitors form the backbone of multiple ...