After 14 days of treatment, 64.6% of the patients taking ... More information: Jun Hamano et al, Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind ...

Naldemedine is efficacious for preventing opioid-induced constipation and for improving QOL among individuals with cancer.

Acute constipation was defined as having ... ECGs, concomitant medications, Objective and Subjective Opioid Withdrawal Scales (OOWS and SOWS), [21] and Numeric Rating Scales for Pain ([NRSP ...

Along with cancer treatment comes pain which has often been treated with opioids. However, these opioids have some adverse effects such as constipation which can diminish one’s quality of life (QOL).

In a randomized manufacturer-sponsored study, the peripheral opioid antagonist methylnaltrexone was investigated as therapy for opioid-induced constipation ... four study-drug doses, defecation ...

Stomachaches and pains can occur for various reasons, including constipation, gas, and heartburn. In some cases, ...

or placebo group in a 1:1 ratio for 14 days with protocol treatment. The primary end point was the proportion of patients with a Bowel Function Index (BFI) of <28.8 on day 14. The secondary end points ...

Researchers at University of Tsukuba revealed that administering naldemedine, which is a constipation medication, alongside opioids effectively prevents opioid-induced constipation, thereby improving ...