. For about a century, the argument for focusing on rare Mendelian disorders was as follows: Mendelian phenotypes will reveal genes involved in common multifactorial traits, metabolic pathways ...

Methods: We employed a bidirectional two-sample Mendelian randomization approach to investigate the causal relationship between schizophrenia and 731 immune cell traits by utilizing public GWAS data.

Therefore, we aimed to elucidate the causality between these traits and LC. Methods: Bidirectional two-sample Mendelian randomization (MR) and bibliometric approaches were conducted to estimate the ...

To better distinguish between these possibilities, we identified 220 gene–trait pairs in which protein-coding variants influence a complex trait or its Mendelian cognate. Despite the presence of ...

We often think of high blood pressure as just a number to check when visiting the doctor, but it affects more than just your ...

Researchers have examined thousands of genetically defined traits to identify possible causal relationships for eight common ...

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This framework is then used to develop statistical tests powered to distinguish between trait tails characterised by common polygenic architecture from those that include substantial enrichments of de ...

Mendelian randomization (MR) is a key methodology in modern epidemiology ... and meta‐analyses is shown for sleep apnea as a causal factor for each of the 3 main traits and their reverse causal ...

Question 1: How do Mendel’s experiments show that traits may be dominant or recessive? Solution : Mendel's experiments with pea plants demonstrated that traits can be either dominant or ...