Because both heterozygotes and hemizygotes are selected for, the mutant allele should eventually predominate in a malaria-exposed population. However, this doesn't happen- there are still males ...

The protein that is coded for by the mutant allele doesn’t function correctly and can distort the shape of red blood cells. If a person has two copies of the mutant allele in their body cells ...

Usually, both genes make a normal hemoglobin protein. When someone inherits two mutant copies of the hemoglobin gene, the abnormal form of the hemoglobin protein causes the red blood cells to lose ...

capable of being ligated to either the wild-type or mutant locus, with precise base stacking continuity with the 5´ end of the P1 probe. An allele-specific base was located at a 3´-hydroxyl ...

(B) Extracted ion chromatograms of the KRas4BG12C allele-specific N-terminal mutant tryptic peptide LVVVGACGVGK identified in control (i.e., 2D cultured NCI-H23 cells) and the sample (i.e., 3D ...