We conclude that deletion of exon 3 results in a Mecp2-null mutation and that disruption of Mecp2 does not lead to embryonic lethality. Both Mecp2-null and Nestin-Cre conditional mutants seemed ...

The evidence for the authors' claims is convincing, combining state-of-the-art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great ...

OSM-3, revealing that the kinase, NEKL-3, phosphorylates a serine/threonine patch at the hinge region of the motor to mediate autoinhibition until it reaches the ciliary middle segment. The findings ...

Genetic polymorphisms have been described in the case of several CYP isoenzymes. The best explored example of this phenomenon is the CYP2C19 polymorphism. In this table the most frequent alleles ...

1 Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN, United States 2 Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School, Worcester, MA, United ...

The quantitative meta-analysis in itself gives no indication of study biases and limitations, but, as outlined below, each graph highlights the near null association, especially when considered ...

The default report template for the VIP report generator. This template is a good default for any .vcf file with support for .vcf files annotated with VIP. The config.json file is used to configure ...

Next, using fluorescent dyes attached to ApoE or to its lipid cargoes, the scientists found that lipidated ApoE3 and ApoE4 readily infiltrated a variety of cells, including H4 neuroglioma cells and ...