Purpose. Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...

in reducing pain in a mouse model without the adverse effects of opioids. (3) The study further explored the underlying mechanisms of how HC-HA/PTX3 produces its effects on neurons, suggesting the ...

Further, the non-addictive nature of Neural Ice stands in contrast to opioid-based pain medications, which can cause dependence and lead to abuse. Neural Ice’s novel temperature-based mechanism of ...

The mechanism of action for the targeted prodrug ... which is currently dominated by addictive opioids." The project will now undergo more pre-clinical trials to determine effectiveness and ...

This study utilizes an elegant approach to examine valence encoding of the mesolimbic dopamine system. The findings are valuable, demonstrating differential responses of dopamine to the same taste ...

In addition, some of the excipients used to prepare oral modified-release opioid products, particularly talc, may lead to serious complications if these products are parenterally abused.

Opioid therapy is limited by analgesic tolerance and hyperalgesia. Here, the authors show that FLT3 in primary sensory neurons drives morphine tolerance and hyperalgesia while its inhibition ...