After 14 days of treatment, 64.6% of the patients taking ... More information: Jun Hamano et al, Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind ...

Naldemedine is efficacious for preventing opioid-induced constipation and for improving QOL among individuals with cancer.

Exclusion criteria included fecal impaction, mechanical bowel obstruction, constipation not attributed to postprocedure opioid use, calculated creatinine clearance less than 50 mL/min, and ...

Of these, 33 received at least 1 dose of study treatment following double-blind ... the study because of AEs (one with moderate constipation, one with mild diarrhea) compared with none of the ...

naldemedine use was associated with constipation prevention and a significant improvement of constipation-related quality of life (QOL) in cancer patients initiating opioid pain therapy. Along with ...

Opioids, potent pain relievers for patients with cancer, frequently cause constipation, which is a significant issue. Researchers at University of Tsukuba revealed that administering naldemedine, ...

Here, we report the preventive effect of naldemedine versus placebo for constipation in patients with cancer starting an opioid therapy in a multicenter ... We conducted rigorous safety assessments on ...