Nature7mon
The as-yet unfulfilled promise of p38 MAPK inhibitors
One target for such inhibition, the p38 mitogen-activated protein kinase (MAPK) signaling cascade, has a role in inflammation by mediating the cellular response to stress, pathogens, and cytokines.
BioWorld3d
GSK-3179106 reduces inflammation and acute lung injury in mice through p38 MAPK targeting
Previous laboratory and clinical studies showed that inhibiting the activation of the MAPK signaling pathway could attenuate acute lung injury.
Nature7mon
Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation
The crystal structure of the catalytic domain from the MAPK phosphatase Pyst1 (Pyst1–CD) has been determined at 2.35 Å. The structure adopts a protein tyrosine phosphatase (PTPase) fold with a ...