p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...
p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...
p53). It will be of considerable interest to determine whether SMO or PTCH1 expression correlates with any other clinically-relevant parameter such as metastatic or osteolytic behavior (Sterling et al ...
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