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TP-53 突变会影响 EGFR-TKI 的疗效吗?
本期我们一起学习一下 TP53 和 EGFR/TP53 共突变 NSCLC 相关的治疗。 TP53 是细胞内一种重要的肿瘤抑制基因,它是包括肺腺癌、肺鳞癌在内的多种不同类型肿瘤中突变频率最高(>50%)的基因,其编码一种分子质量为 53kDa 的转录因子蛋白,即 p53。在日常使用过程中也 ...
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