The PIK3CA wild-type cohort of the Phase 3 VIKTORIA-1 trial is 100% enrolled; expect to report topline data for this cohort in late Q1 2025 or Q2 2025Approximately $264 million in cash, cash ...

Cancer remains one of the leading global causes of mortality, with an estimated increase in cases due to lifestyle, ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

Cancer remains one of the leading global causes of mortality, with an estimated increase in cases due to lifestyle, environmental, and genetic ...

Cancer is thought to be the second most prevalent and leading cause of mortality worldwide, affecting both men and women among other chronic diseases. While there are several treatment options ...

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...

Adam Brufsky, MD, PhD, professor of medicine at the University of Pittsburgh School of Medicine; Megan Kruse, MD, breast medical oncologist at Cleveland Clinic; and Ruta Rao, MD, professor of medicine ...

Zhejiang Province Key Laboratory of Smart Management & Application of Modern Agricultural Re-sources, School of Information Engineering, Huzhou University, Huzhou 313000, Zhejiang Province,China ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3 ...

However, this company is looking to change the scope of PI3K-alpha [PI3Ka] targeting by going after specific mutation types while sparring wild-type enzyme in healthy human tissues. It believes ...

Agencies have a new way to connect with qualified early-career workers and move them from the Pathways Program into full-time federal jobs. Two new “talent programs” on USAJobs, which the Office of ...