AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...

10月16日，国际心脏研究学会官方杂志Journal of Molecular and Cellular Cardiology在线发表了中国科学院上海营养与健康研究所杨黄恬研究团队题为“Human embryonic stem cell-derived cardiovascular progenitor cells stimulate cardiomyocyte cell cycle ...

2024 年 11 月 6 日，我院 天然药物及仿生药物全国重点实验室 PI 崔一民教授团队与刘振明研究员团队合作在 Advanced Science 发表了最新研究成果 “Targeting SLITRK4 Restrains Proliferation and Liver Metastasis in Colorectal Cancer Via Regulating PI3K/AKT/ NFκB ...

Cell lines exhibiting aerobic glycolysis are glucose-dependent because the PI3K/Akt/TOR pathway directs other metabolic substrates into lipid and protein synthesis. Interestingly, the ability of Akt ...

Murine Kras-driven lung cancer models have confirmed the key requirements for RAF, PI3K and RAL-GEF in vivo. Co-opted pathways required by oncogenic KRAS in order to sustain lung tumorigenesis ...

The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central regulator of various cellular ...

The company’s lead development candidate is Paxalisib, a small molecule, brain-penetrant inhibitor of the PI3K/AKT/mTOR pathway, which is developed as a potential therapy for glioblastoma.