In what felt like a potential Final Four preview, the visiting No. 6 Notre Dame Irish, who led wire to wire, played spoiler to a crowd of 7,894 at Galen Center in Los Angeles, defeating No. 3 USC 74-61 to hand the Trojans their first loss of the season.

Hannah Hidalgo scored 24 points and No. 6 Notre Dame defeated JuJu Watkins and third-ranked Southern California 74-61 on Saturday in a marquee matchup on the West Coast. Watkins and the Trojans (4-1) fell behind early and were down 21 points in the fourth quarter.

Generally November battles between Notre Dame and USC with both teams ranked in the nation's top 10 are reserved for football. Saturday however saw the No. 6 Notre Dame women's basketball team travel to Los Angeles and take care of business against No.

Notre Dame is a win over USC away from a spot in the College Football Playoff and a likely first-round game at home. The No. 6 Fighting Irish blew out No. 19 Army, 49-14, to end the Black Knights’ bid for an undefeated season.

Yahoo Sports basketball analyst Isis "Ice" Young reacts to the Fighting Irish's 74-61 over the Trojans and discusses how Notre Dame was able to force a tough shooting day from USC's superstar guard.

No. 3 USC will face their biggest challenge of this early season on Saturday (4 p.m. ET, NBC) against No. 6 Notre Dame.