Skeletal stem cells (SSCs) are heterogeneous in population and have multipotent ... In particular, in vivo identity and specific regulatory mechanism of adult periosteum-resident SSCs are unknown and ...

Mesenchymal stem cells are a rare population of undifferentiated cells, isolated from adult tissue sources, that have the capacity to differentiate into mesodermal lineages, including bone ...

More recently, we discovered adult SSC heterogeneity and a long-term repopulating SSC subset present in periosteum (outer layer of bone) with a unique CCL5-dependent migratory mechanism required for ...