CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...

Methods We employed bioinformatics analysis to investigate molecular signatures, aiming to shed light on the pathogenesis of DM. The expression of protein kinase R (PKR) in DM muscle tissues was ...

As society ages, the number of patients suffering from heart failure grows significantly. Fibrosis, or excessive growth of fibrotic tissue in the heart, has been linked to the advancement of heart ...

We engineered 44 yeast strains each expressing a tyrosine kinase, and quantitatively analysed their phosphoproteomes. This ...

Google DeepMind, in collaboration with Isomorphic Labs, has predicted over 200 million protein structures using AlphaFold by training the model with nearly 100,000 known proteins, driving significant ...

Kim, J. and Sadiora, K. (2024) Systematic Analysis of Post-Translational Modifications for Increased Longevity of ...

A protein called torsinA plays a key role in ... and their colleagues tracked the number and placement of these structures in neurons growing in petri dishes isolated from animals soon after ...

Protein is vital to the functioning of cells in living organisms. Proteins are required for the structure and regulation of the body’s tissues and organs. They are made up of long chains of amino ...

Unlike their well-known, folded counterparts, intrinsically disordered proteins lack a single, stable three-dimensional structure. Instead, like Proteus, they take on many different conformations. 1 ...

Copper is an essential enzyme cofactor in bacteria, but excess copper is highly toxic. Bacteria can cope with copper stress by increasing copper resistance and initiating chemorepellent response.