Although the role of innate immune sensing pathways is well-studied in the pathogenesis of malignancies, whether they ...

One of the things that makes brains so incredibly difficult to understand is their ability to adjust and adapt. Our learning ...

This important study using engineered mouse models provides a first and compelling demonstration of a pathogenic phenotype associated with lack of expression of p53AS, an isoform of the p53 protein ...

Experimental mRNA Cancer Vaccine Shows Potential for Advanced Stage Cancer Patients in Phase 1 TrialInterim data from the ...

The enzyme converts heart fibroblasts to myofibroblasts, putting the heart's integrity at risk. Deleting this enzyme reduced ...

The enzyme protein kinase N (PKN) has been implicated in a signaling cascade that causes heart fibroblast activation. A group ...

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A team at Nagoya University Graduate School of Medicine has found that the enzyme protein kinase N (PKN) plays a role in ...

As society ages, the number of patients with heart failure is rapidly increasing. Excessive growth of fibrotic tissue in the ...

Changing nutrient environments challenge cells as they affect both protein biosynthesis and cell cycle length. This work ...