Novel macrocyclic heteroaryl derivatives acting as non-receptor tyrosine-protein kinase TYK2 and/or JAK1 and/or JAK2 inhibitors have been reported in a Hangzhou Highlightll Pharmaceutical Co. Ltd.

Data demonstrate potential superiority of a targeted protein degradation strategy compared to kinase inhibition for both BTK ...

Recent data suggests a direct link between the surface estrogen receptor and the mitogen-activated protein (MAP) kinase signaling cascade. MAP kinases are a family of serine–threonine kinases ...

Researchers reveal that spermidine-mediated acetylhypusination of RIPK1 suppresses necroptosis and insulin resistance, ...

Two kinase inhibitors have been recommended by the European Medicines Agency for the treatment of non-small cell lung cancer.

Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has synthesized compounds acting as tyrosine-protein kinase receptor UFO (AXL) inhibitors reported to be useful for the treatment of cancer.

AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...

Sodium butyrate modulates necroptosis in intestinal epithelial cells during liver cirrhosis, offering potential therapeutic ...

This bioinformatics-assisted review describes key biological elements of known pathways, such as the forkhead box protein ...

Targeted therapy revolutionized cancer treatment, with gene fusions leading the way when the FDA approved imatinib in 2001 to ...

Scientists speculate that Semaglutide, as a GLP-1 receptor analog, represents a peptide with broad research potential beyond ...