Recent data suggests a direct link between the surface estrogen receptor and the mitogen-activated protein (MAP) kinase signaling cascade. MAP kinases are a family of serine–threonine kinases ...

Calcium that enters the receptor induces activation of calcium/calmodulin-dependent protein kinase II, which in turn interacts with the NMDA receptor and thus comes into close proximity with the ...

The Falke group is currently investigating the molecular mechanisms of on-off switching of components within the chemosensory array, especially the mechanisms by which transmembrane receptors bind ...

WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and ...

In the study, "Melatonin receptor 1A variants as genetic cause ... and mitogen-activated protein kinase pathways, which ...

Novel macrocyclic heteroaryl derivatives acting as non-receptor tyrosine-protein kinase TYK2 and/or JAK1 and/or JAK2 inhibitors have been reported in a Hangzhou Highlightll Pharmaceutical Co. Ltd.

Medically reviewed by Mary Choy, PharmD Biologics work by targeting proteins that cause inflammation in ulcerative colitis.

Two kinase inhibitors have been recommended by the European Medicines Agency for the treatment of non-small cell lung cancer.