在RNA提取过程中，RNA酶污染是一个不容忽视的问题。由于RNA酶广泛存在且稳定性极高，它极易导致RNA降解，从而影响后续实验的准确性。为了有效避免RNA酶的干扰，我们可以采取以下几种策略。

Mitochondrial DNA (mtDNA)-encoded RNA molecules undergo extensive processing to generate mature RNA, including removal of ...

Revenue: Revenue for the three months ended September 30, 2024, increased to approximately $1,958,000 compared to $397,000 ...

*仅供医学专业人士阅读参考还记得不久前奇点糕提过，化疗“老将”紫杉醇其实能成为免疫治疗的好帮手，通过多种机制增效免疫治疗，但实话说，奇点糕可没指望癌细胞们见到免疫治疗和紫杉醇就乖乖束手就擒，不然三阴性乳腺癌（TNBC）之类的免疫“冷肿瘤”，早就被联合 ...

导读：环状RNA（circRNA）疫苗因稳定闭环结构和持久的蛋白表达能力而受到关注。在制备过程中产生的nicked circRNA与完整circRNA分子量相似，基于分子量差异的分析技术（如CE）难以区分二者。且circRNA的降解模式、特征降解产物及其生物活性尚不清楚。 2024年，中检 ...

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Here, we report that cells lacking two enzymes involved in R loop removal—senataxin and RNase H2—exhibit increased R loop formation and genome instability at the immunoglobulin heavy-chain locus ...

Bacterial toxins are toxic substances that are produced and released by bacteria to target other bacterial or host cells. Bacteria often have antitoxins to avoid the deleterious effects of toxins ...

This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops also compromise DNA repair. Depleting endogenous RNase H activity impairs ...