alongside opioids effectively prevents opioid-induced constipation, thereby improving the patient's quality of life. Pain relief for patients with cancer is crucial, and opioids, such as morphine ...

Naldemedine is efficacious for preventing opioid-induced constipation and for improving QOL among individuals with cancer.

Exclusion criteria included fecal impaction, mechanical bowel obstruction, constipation not attributed to postprocedure opioid use, calculated creatinine clearance less than 50 mL/min, and ...

Of these, 33 received at least 1 dose of study treatment following double-blind ... the study because of AEs (one with moderate constipation, one with mild diarrhea) compared with none of the ...

Along with cancer treatment comes pain which has often been treated with opioids. However, these opioids have some adverse effects such as constipation which can diminish one’s quality of life (QOL).

or placebo group in a 1:1 ratio for 14 days with protocol treatment. The primary end point was the proportion of patients with a Bowel Function Index (BFI) of <28.8 on day 14. The secondary end points ...

Naldemedine was effective in preventing opioid-induced constipation (OIC ... aged 20 years or older who were given first time regular treatment with a strong opioid for cancer pain were included.

Stomachaches and pains can occur for various reasons, including constipation, gas, and heartburn. In some cases, ...