The endoplasmic reticulum (ER)-localized transmembrane proteins IRE1, PERK and ATF6 detect the load of unfolded protein in the lumen of the organelle, serving as stress receptors. They transduce ...
Some of those proteins stretch the endoplasmic reticulum, creating protective vesicles, or sacs. The virus uses its own RNA copying machine, called a polymerase, to make duplicates of RNA inside ...
The study presents important findings on inositol-requiring enzyme (IRE1α) inhibition on diet-induced obesity (overnutrition) and insulin resistance where IRE1α inhibition enhances thermogenesis and ...