Fluorescence microbeads, Transwell and ROS kit were used to detect the phagocytosis, migration and ROS clearing capability of BMDM. Western blot was used to detect the expression of JAK2/STAT3 pathway ...

Furthermore, IL-6 activated the JAK2/STAT3 signaling pathway to suppress cell autophagy and promoted ECs calcification. Discussion: ECs are not only critical for atherogenesis but also believed to be ...

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EAC is one of the leading causes of cancer death in the USA and Western countries, where standard chemotherapy has limited efficacy ... 8 13 14 APE1 redox function is critical for protecting cellular ...

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Inhibition of Rac1 by EHT1864 showed that Rac1 signalling controlled human aSMC proliferation induced by mitogenic stimuli through the signal transducer and activator of transcription 3 (STAT3) ...

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This important study investigates the molecular mechanisms underpinning how the tumor necrosis factor alpha-induced protein (TIPE) regulates aerobic glycolysis to promote tumor growth in melanoma.