[68,69] Doxycycline (a tetracycline) was shown to inhibit superantigen-induced T-cell proliferation and cytokine and chemokine production by PMN cells in vitro. [70] Therefore, these antibiotics ...
Interactions with self-peptide–MHC complexes on thymic epithelial cells are crucial for thymocyte survival (positive selection) and CD4 versus CD8 lineage commitment, but can also result in ...