Melanoma is the most serious type of skin cancer. It develops when skin cells multiply rapidly as a consequence of mutations in their DNA caused by UV exposure. Melanomas originate in the pigment ...

Cryo-electron microscopy reveals the mechanism of human translation initiation from codon scanning to subunit joining. The structures show the roles of the Kozak sequence, GTP hydrolysis by ...

1 Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China 2 Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China Although FTO gene ...

Introduction: Neuropathic pain (NP) conditions arising from injuries to the nervous system due to trauma, disease, or neurotoxins are chronic, severe, debilitating, and exceedingly difficult to treat.

The untranslated regions (UTRs) of mRNAs harbor regulatory elements influencing translation efficiency. Although 3.7% of disease-relevant human mutations occur in UTRs, their exact role in ...