Migratory DCs carry peripheral self antigens into the thymus and thereby may extend ... an autonomous APC function not only in CD8 + but also in CD4 + T cell tolerance. Constitutive and ...

Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. In this immunofluorescence image ... In the first place, naïve T-lymphocytes are those cells ...

Cell suspensions were prepared from the spleen or thymus by pushing the tissue through a nylon mesh using the plunger of a 2-ml syringe in cold PBS containing 0.1% BSA. Whole blood or 100 μL of ...

The decrease in CD4 cells during HIV infection seems to be ... and higher LPS levels were associated with greater activation of CD8 + lymphocytes. CD8 + activation also was found to be higher ...

Flow cytometric analysis. The lymphocyte composition of lymphoid organs was determined following triple staining with antibodies against CD4, CD8, and B220. Effector/memory CD4+ T cells were ...

Mice express full-length protein ZBP1-L as well as an alternatively-spliced shorter isoform (ZBP1-S) containing only its two ...

MA Farage and KW Miller are employees of Proctor and Gamble. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in ...

As a cellular immunologist I study the development of T lymphocytes in the thymus and the response of mature T cells to pathogens. The focus of study is the subset of T cells that bear the CD8 marker ...

Since HRES-1/Rab4 targets CD3ζ and CD4 for lysosomal degradation, we examined this process in NZB/W F1 mice ... was robustly overexpressed in the spleen and thymus of lupus-prone mice. The activation ...