These intracellular signaling pathways, also called signal transduction cascades, typically amplify the message, producing multiple intracellular signals for every one receptor that is bound.

Mapping the key signaling molecules in biochemical pathways will be central to future drug discovery efforts. Signal transduction describes the process of conversion of external signals ...

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause the dysregulation of growth and inhibition of apoptosis that characterize advanced ...

Members of the program engage in research aimed at obtaining a mechanistic understanding of signal transduction and cellular regulation, which includes cellular signaling pathways and downstream ...

Signal transduction across membranes through regulated intramembrane proteolysis is conserved throughout all domains of life. In the SREBP pathway of human cells, the membrane-bound SREBP ...