THE GLOBAL health burden of inflammatory bowel disease (IBD) is increasingly prevalent in today’s world, partly due to ...

Tyrosine kinase 2 (TYK2) critically regulates tau levels and aggregation by phosphorylating tau’s tyrosine 29. Partial inhibition of TYK2 mitigates tau pathologies in cells and mice ...

MoonLake Immunotherapeutics' shares have dipped recently, with a catalyst vacuum until mid-2025 when pivotal trial data for ...

As a non-receptor tyrosine kinase, TYK2 is a member of the JAK kinase family, which is an important kinase on the JAK-STAT signaling pathway and plays an important role in the pathogenesis of ...

Alumis' lead clinical candidate, ESK-001, is a potent, highly selective allosteric tyrosine kinase 2 (TYK2) inhibitor that reduces signaling through several cytokine receptors including receptors for ...

Researchers discovered that the enzyme TYK2 alters the tau protein, promoting its accumulation in the brain, a process linked to Alzheimer’s disease in animal models. Partially inhibiting TYK2 could ...

Published in Nature Neuroscience, the study suggests that partially restraining TYK2 could be a strategy to reduce tau levels and toxicity. "Many studies have shown that the accumulation of tau in ...

A new report from the Los Angeles Regional Consortium (LARC) and the Career Ladders Project (CLP) details one initiative to building and scaling dual-enrollment pathways and the elements of a ...

Key Laboratory of Advanced Energy Materials Chemistry, Ministry of Education State Key Laboratory of Advanced Chemical Power Sources Collaborative Innovation Center of Chemical Science and Engineering ...

Researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital and collaborating institutions discovered that the enzyme ...

By reducing TYK2 activity in animal models, researchers found tau buildup was decreased, suggesting TYK2 inhibitors could be a potential therapeutic pathway. The findings could eventually help prevent ...