These are ATP-independent proteasome regulators that modulate proteasome activity towards small peptides and unfolded proteins and can facilitate protein degradation independent of ubiquitin (Toste ...

In summary, we have developed a flexible and facile method of manipulating protein half-life and steady-state concentration that utilizes components of the ubiquitin–proteasome pathway.

The BSN Pathway is built on a traditional four-year undergraduate curriculum that provides a foundational education that includes both academic and professional nursing courses essential for clinical ...

The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated cellular proteins. Removal of ubiquitin chains from targeted substrates at the proteasome is a ...