Notch activity can counteract VEGF-C-dependent (lymph)angiogenesis in KSHV-infected lymphatic endothelial cells, further supporting the central role of Notch signaling in cell fate determination.

However, tumor vasculature is abnormal, chaotic and leaky due to the high production of angiogenic factors such as VEGF. In tumors, Dll4/Notch signaling appears to dampen (much like a resistor in ...

The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be ...